The 10th ISCC
January 26-27, 2006
Keidanren Hall
January 26, 2006 (Thursday)
Opening Address
12:50-13:00
Edward A. Sausville (Univ. Maryland, Baltimore)
Memorial Lecture of the 10th Symposium
Chairperson: Jean-Pierre Armand (Institut Gustave-Roussy, Paris)
13:00-13:40
Haruo Sugano (Cancer Chemotherapy Center, Tokyo)
Historical view of drug development and chemotherapy in Japan
Growth Signal and Inhibitors ( Session 1)
Chairpersons: Michael M. Gottesman (NCI, NIH, Bethesda)
Nagahiro
Saijo (National Cancer Center Hospital East, Kashiwa)
13:40-14:20
Bruce A. Chabner (Massachusetts General Hospital, Boston)
Lessons from the early results of EGFR inhibitors
14:20-15:00
Tetsu Akiyama (Univ. Tokyo, Tokyo)
Function of the tumor suppressor APC
15:00-15:10
Discussion
15:10-15:30
Coffee Break
Growth Signal and Inhibitors ( Session 2)
Chairpersons: Bruce A. Chabner (Massachusetts General
Hospital, Boston)
Yoshiro Niitsu (Sapporo Med. Univ., Sapporo)
15:30-16:00
Edward A. Sausville (Univ. Maryland, Baltimore)
Update on Geldanamycin analogues
16:00-16:30
Takao Yamori (Cancer Chemotherapy Center, Tokyo)
A novel phosphatidylinositol 3-kinase inhibitor, ZSTK474, and its preclinical activity
16:30-17:00
Robert H. Shoemaker (NCI-FCRDC, Frederick)
Targeting CHK2 kinase for cancer therapy
Growth Signal and Inhibitors ( Session 3)
Chairpersons: Yutaka Ariyoshi (Aichi Hospital, Nagoya)
Kiyohiko Hatake (Cancer Chemotherapy Center, Tokyo)
17:00-17:30
Jean-Pierre Armand (Institut Gustave-Roussy, Paris)
Treatment of kidney cancer: the mutation!
17:30-18:00
Hideyuki Akaza (Tsukuba Univ., Tsukuba)
New treatment for renal cell cancer
18:00-18:30
Discussion
18:30-19:30
Mixer
January 27, 2006 (Friday)
Drug Resistance and Sensitivity (Session 1)
Chairpersons: Isaiah J. Fidler (UT M.D. Anderson Cancer
Center, Houston)
Ryuzo Ueda (Nagoya City Univ., Nagoya)
09:30-10:10
Victor Ling (BC Cancer Research Center, Vancouver)
Predicting response to cancer chemotherapy
10:10-10:30
Coffee Break
10:30-11:10
Yuichi Sugiyama (Univ. Tokyo, Tokyo)
Role of ABC transporters in the pharmacokinetics of drugs in the intestine, liver, kidney and brain
11:10-11:50
Michael M. Gottesman (NCI, NIH, Bethesda)
New approaches to multidrug resistance in cancer
11:50-12:00
Discussion
Drug Resistance and Sensitivity (Session 2)
Chairpersons: Edward A. Sausville (Univ. Maryland, Baltimore)
Masahiro
Fukuoka (Kinki Univ., Osaka)
12:00-12:30
Saburo Sone (Univ. Tokushima, Tokushima)
Real-time PCR-based biomarker to predict the sensitivity of non-small cell lung cancer to EGFR-TKI
12:30-13:00
Nagahiro Saijo (National Cancer Center Hospital East, Kashiwa)
Clinical development and problem of EGFR TKI
13:00-13:10
Discussion
13:10-14:00
Lunch Break
Metastasis and Regulation (Session 1)
Chairpersons: Jaap Verweij (Erasmus Univ. Medical Center,
Rotterdam)
Saburo
Sone (Univ. Tokushima, Tokushima)
14:00-14:40
Isaiah J. Fidler (UT M.D. Anderson Cancer Center, Houston)
Anti-vascular therapy of cancer metastasis
14:40-15:20
Yoshimi Takai (Osaka Univ., Suita)
New cross talk mechanisms of cell adhesion, migration and proliferation
15:20-15:30
Discussion
15:30-15:50
Coffee Break
Metastasis and Regulation (Session 2)
Chairpersons: Robert H. Shoemaker (NCI-FCRDC, Frederick)
Michihiko
Kuwano (Kurume Univ., Kurume)
15:50-16:20
Jaap Verweij (Erasmus Univ. Medical Center, Rotterdam)
ABT-510, the first clinically active thrombospondin-mimetic
16:20-16:50
Yasufumi Sato (Tohoku Univ., Sendai)
An endothelium-derived angiogenesis inhibitor vasohibin and
its significance in tumor angiogenesis
16:50-17:10
Discussion
Special Lecture of the 10th Symposium
Chairperson: Victor Ling (BC Cancer Research Center, Vancouver)
17:10-18:00
Takashi Tsuruo (Univ. Tokyo, Tokyo)
Drug resistance as a target for cancer chemotherapy
Closing Remark
18:00-18:10
Bruce A. Chabner (Massachusetts General Hospital, Boston)
