The 10th ISCC

January 26-27, 2006
Keidanren Hall

January 26, 2006 (Thursday)

Opening Address

12:50-13:00

Edward A. Sausville (Univ. Maryland, Baltimore)

Memorial Lecture of the 10th Symposium

Chairperson: Jean-Pierre Armand (Institut Gustave-Roussy, Paris)

13:00-13:40

Haruo Sugano (Cancer Chemotherapy Center, Tokyo)

Historical view of drug development and chemotherapy in Japan

Growth Signal and Inhibitors ( Session 1)

Chairpersons: Michael M. Gottesman (NCI, NIH, Bethesda)
Nagahiro Saijo (National Cancer Center Hospital East, Kashiwa)

13:40-14:20

Bruce A. Chabner (Massachusetts General Hospital, Boston)

Lessons from the early results of EGFR inhibitors

14:20-15:00

Tetsu Akiyama (Univ. Tokyo, Tokyo)

Function of the tumor suppressor APC

15:00-15:10

Discussion

15:10-15:30

Coffee Break

Growth Signal and Inhibitors ( Session 2)

Chairpersons: Bruce A. Chabner (Massachusetts General Hospital, Boston)
Yoshiro Niitsu (Sapporo Med. Univ., Sapporo)

15:30-16:00

Edward A. Sausville (Univ. Maryland, Baltimore)

Update on Geldanamycin analogues

16:00-16:30

Takao Yamori (Cancer Chemotherapy Center, Tokyo)

A novel phosphatidylinositol 3-kinase inhibitor, ZSTK474, and its preclinical activity

16:30-17:00

Robert H. Shoemaker (NCI-FCRDC, Frederick)

Targeting CHK2 kinase for cancer therapy

Growth Signal and Inhibitors ( Session 3)

Chairpersons: Yutaka Ariyoshi (Aichi Hospital, Nagoya)
Kiyohiko Hatake (Cancer Chemotherapy Center, Tokyo)

17:00-17:30

Jean-Pierre Armand (Institut Gustave-Roussy, Paris)

Treatment of kidney cancer: the mutation!

17:30-18:00

Hideyuki Akaza (Tsukuba Univ., Tsukuba)

New treatment for renal cell cancer

18:00-18:30

Discussion

18:30-19:30

Mixer

January 27, 2006 (Friday)

Drug Resistance and Sensitivity (Session 1)

Chairpersons: Isaiah J. Fidler (UT M.D. Anderson Cancer Center, Houston)
Ryuzo Ueda (Nagoya City Univ., Nagoya)

09:30-10:10

Victor Ling (BC Cancer Research Center, Vancouver)

Predicting response to cancer chemotherapy

10:10-10:30

Coffee Break

10:30-11:10

Yuichi Sugiyama (Univ. Tokyo, Tokyo)

Role of ABC transporters in the pharmacokinetics of drugs in the intestine, liver, kidney and brain

11:10-11:50

Michael M. Gottesman (NCI, NIH, Bethesda)

New approaches to multidrug resistance in cancer

11:50-12:00

Discussion

Drug Resistance and Sensitivity (Session 2)

Chairpersons: Edward A. Sausville (Univ. Maryland, Baltimore)
Masahiro Fukuoka (Kinki Univ., Osaka)

12:00-12:30

Saburo Sone (Univ. Tokushima, Tokushima)

Real-time PCR-based biomarker to predict the sensitivity of non-small cell lung cancer to EGFR-TKI

12:30-13:00

Nagahiro Saijo (National Cancer Center Hospital East, Kashiwa)

Clinical development and problem of EGFR TKI

13:00-13:10

Discussion

13:10-14:00

Lunch Break

Metastasis and Regulation (Session 1)

Chairpersons: Jaap Verweij (Erasmus Univ. Medical Center, Rotterdam)
Saburo Sone (Univ. Tokushima, Tokushima)

14:00-14:40

Isaiah J. Fidler (UT M.D. Anderson Cancer Center, Houston)

Anti-vascular therapy of cancer metastasis

14:40-15:20

Yoshimi Takai (Osaka Univ., Suita)

New cross talk mechanisms of cell adhesion, migration and proliferation

15:20-15:30

Discussion

15:30-15:50

Coffee Break

Metastasis and Regulation (Session 2)

Chairpersons: Robert H. Shoemaker (NCI-FCRDC, Frederick)
Michihiko Kuwano (Kurume Univ., Kurume)

15:50-16:20

Jaap Verweij (Erasmus Univ. Medical Center, Rotterdam)

ABT-510, the first clinically active thrombospondin-mimetic

16:20-16:50

Yasufumi Sato (Tohoku Univ., Sendai)

An endothelium-derived angiogenesis inhibitor vasohibin and

its significance in tumor angiogenesis

16:50-17:10

Discussion

Special Lecture of the 10th Symposium

Chairperson: Victor Ling (BC Cancer Research Center, Vancouver)

17:10-18:00

Takashi Tsuruo (Univ. Tokyo, Tokyo)

Drug resistance as a target for cancer chemotherapy

Closing Remark

18:00-18:10

Bruce A. Chabner (Massachusetts General Hospital, Boston)

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