The 20th JFCR-ISCC

December 9 (Wed)- 10 (Thu), 2015
Miraikan (National Museum of Emerging Science and Innovation)
2-3-6, Aomi, Koto-ku, Tokyo, Japan

The 20th JFCR-International Symposium on Cancer Chemotherapy (JFCR-ISCC) is scheduled as indicated above.
The JFCR-ISCC aims at information exchange on the latest findings of newly developing molecular-targeted anti-cancer drugs and the related topics. Molecular-targeted anti-cancer drugs have been developing prominently with global standards. Meanwhile, already launched molecular-targeted drugs have often been faced with rather quickly acquired resistance, and various challenges against the resistance are rapidly evolving. Accessing to these information is indispensable, moreover, informal exchanges of personal, very specific, or even unsuccessful experiences, are critically valuable for effective achievements of future drug development. I, as the Chairman of the JFCR-ISCC, believe the Symposium with relatively small size will provide you an excellent opportunity for such communication through personal contacts.
In the upcoming 20th JFCR-ISCC, drug resistance, immunotherapy, precision medicine and epigenetics are the focused topics. I hope the Symposium would be an excellent occasion for you to access the domestic and international developments of new anti-cancer drugs and also to meet scientists, clinicians, and drug developers. So, I sincerely welcome your participation in the Symposium.

Looking forward to seeing you in Tokyo,

Naoya Fujita, Ph.D.
Chairman, JFCR-ISCC
Center Director, Cancer Chemotherapy Center, JFCR


The 20th Symposium Program Committee

Naoya Fujita (Program Committee Chairman, Cancer Chemotherapy Center, JFCR)

Nobuaki Adachi (Daiichi Sankyo Co., Ltd.)
Shiro Akinaga (Kyowa Hakko Kirin Co., Ltd.)
Yuko Aoki (Chugai Pharmaceutical Co., Ltd.)
Shingo Dan (Cancer Chemotherapy Center, JFCR)
Kiyohiko Hatake (Cancer Chemotherapy Center, JFCR)
Seiji Ito (Bristol-Myers K.K.)
Masao Iwata (Eisai Co., Ltd.)
Hiroshi Miyake (Takeda Pharmaceutical Co. Ltd.)
Kei Muro (Aichi Cancer Center Hospital)
Hiroyoshi Nishikawa (National Cancer Center)
Atsushi Ohtsu (National Cancer Center)
Isamu Okamoto (Kyushu University)
Hiroyuki Seimiya (Cancer Chemotherapy Center, JFCR)
Kenji Suzuki (Taiho Pharmaceutical Co., Ltd.)
Kazuhito Yamamoto (Aichi Cancer Center Hospital)


December 9


Poster mounting


Committee meeting

Opening Remark


Naoya Fujita (Cancer Chemotherapy Center, JFCR, Tokyo)

Opening remark

IA new era of immuno-oncology

Chairpersons: Stefan Sleijfer (Erasmus Medical Center Cancer Institute, Rotterdam, Netherlands)
Hiroyoshi Nishikawa (National Cancer Center, Kashiwa)


Alan J. Korman (Bristol-Myers Squibb, Redwood City, USA)

Antitumor activity of immunomodulatory antibodies – anti-CTLA-4 and anti-PD-1


Keiya Ozawa (The University of Tokyo , Tokyo)

CD19-specific CAR (chimeric antigen receptor)-expressing T cell gene therapy for B cell malignancies


Timothy A. Chan (Memorial Sloan Kettering Cancer Center, New York, USA)

Genomic landscapes and response to immune-based therapy




Coffee break

II Toward precision cancer medicine

Chairpersons: Anthony W. Tolcher (START, San Antonio, USA)
Atsushi Ohtsu (National Cancer Center, Kashiwa)


Lillian L. Siu (Princess Margaret Cancer Centre, Tronto, Canada)

Genomic based clinical trials – now and next generation


Katsuya Tsuchihara (National Cancer Center, Kashiwa)

A nation-wide genome prescreening program stratifying lung and gastrointestinal cancer patients, SCRUM-Japan


Stefan Sleijfer (Erasmus Medical Center Cancer Institute, Rotterdam, Netherlands)

Liquid biopsies; potential valuable tool in drug development studies



Poster Session


Saori Miyano (Eisai Co., Ltd., Tsukuba)

Characterization of E7090: A novel and selective FGFR inhibitor

Yusuke Ogitani (Daiichi Sankyo Co., Ltd. , Tokyo)

DS-8201a, a novel HER2-targeting ADC with a novel DNA topoisomerase I inhibitor, demonstrates a potent anti-tumor efficacy with differentiation from T-DM1 in preclinical studies

Takahiro Nakamura (Cancer Chemotherapy Center, JFCR, Tokyo)

Glioma stem cell-selective antitumor effect of a novel G-quadruplex ligand

Li Wang (Anaeropharma Science, Inc., Tokyo)

i-DPS (in situ Delivery and Production System): A “smart” drug delivery technology to deliver and produce immune checkpoint blockers inside hypoxic tumor

Kosei Toyoshima (Takeda Pharmaceutical Co. Ltd., Fujisawa)

Analysis of circulating tumor cells derived from advanced gastric cancer

Hiromichi Kosaka (Kyowa Hakko Kirin Co., Ltd., Suntou)

Small molecule metabolic inhibitors, compound A and the derivatives specifically inhibit the cell growth of Ewing’s sarcoma cells harbor EWS-FLI1 in vitro and in vivo

Takahiko Seki (Daiichi Sankyo Co., Ltd. , Tokyo)

Pharmacological profile of MDM2 inhibitor DS-3032b and its biomarker approach (provisional titile)

Yoshiaki Nakamura (National Cancer Center, Kashiwa)

Mechanism-based epigenetic combination therapy of gastric cancer

Takahiro Ishiguro (Chugai Pharmaceutical Co., Ltd., Tokyo)

Identification and optimization of T cell-redirecting asymmetric bispecific fully IgG antibody - Next approach to cancer immunotherapy -

Yuko Kawano (Kyushu Univ., Fukuoka)

Expression of CD44 variants in EGFR-mutation positive non-small cell lung cancer (NSCLC)

Keiichi Ota (Kyushu Univ., Fukuoka)

Induction of PD-L1 expression by the EML4–ALK oncoprotein and downstream signaling pathways in Non–Small cell lung cancer

Danbee Ha (National Cancer Center, Kashiwa)

Anergic T cells naturally present in humans are immunosuppresive



December 10

III Targeting epigenetics for cancer therapy

Chairpersons: Timothy A. Chan (Memorial Sloan Kettering Cancer Center, New York, USA)
Tomoki Naoe (NHO Nagoya Medical Center, Nagoya)


Yutaka Kondo (Nagoya City University, Nagoya)

Clinical implications of epigenetic alterations in human tumors


Tom Heightman (Astex Pharmaceuticals, Cambridge, UK)

Discovery and development of SGI-110 (guadecitabine), a second generation hypomethylating agent with clinical efficacy




Coffee break

Poster Discussion Session

Chairperson: Yoshikazu Sugimoto (Keio University, Tokyo)


Mentor: 1: Anthony W. Tolcher

Mentor: 2: Stefan Sleijfer

Mentor: 3: Lillian L. Siu

Luncheon Seminar

Chairperson: Kensei Yamaguchi (Cancer Institute Hospital, JFCR, Tokyo)


Teiji Takechi (Taiho Pharmaceutical Co., Ltd. , Tokyo)

TAS-102, a novel oral antitumor drug consisting of trifluridine and tipiracil hydrochloride


Poster removal

Meet-the-Expert Seminar

Chairperson: Mitsuaki Yoshida (JFCR, Tokyo)


Alice Shaw (MGH Cancer Center, Boston, USA)

Next generation ALK/ROS1 inhibitors in NSCLC


Coffee break

IV Molecular mechanisms of drug resistance and rational drug combinations

Chairpersons: Lillian L. Siu (Princess Margaret Cancer Centre, Tronto, Canada)
Isamu Okamoto (Kyushu University, Fukuoka)


Hiromichi Ebi (Kanazawa University, Kanazawa)

Combinatorial approach targeting KRAS mutant cancers


Ryan B. Corcoran (MGH Cancer Center, Boston, USA)

Targeted therapy approaches to overcome drug resistance and tumor heterogeneity


Anthony W. Tolcher (START, San Antonio, USA)

Antitumor activity in RAS-driven tumors by blocking AKT and MEK



V New targets and drugs under clinical or preclinical investigations

Chairpersons: Ryan B. Corcoran (MGH Cancer Center, Boston, USA)
Hiroyuki Seimiya (Cancer Chemotherapy Center, JFCR, Tokyo )


Tesshi Yamada (National Cancer Center, Tokyo)

Targeting the Wnt signaling pathway in colorectal cancer


Mikihiko Naito (National Institute of Health Sciences, Tokyo)

Protein knockdown by SNIPER compounds, inducers for target protein-selective degradation



Closing Remark


Anthony W. Tolcher (START, San Antonio, USA)

Closing remark

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